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Fosamin Oral Powder 3gm Sachet
Fosfomycin/Fosamin is specifically indicated for the treatment of uncomplicated urinary tract infections (acute cystitis) in women, caused by susceptible strains of Escherichia coli and Enterococcus faecalis.
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✅ Description:
Fosfomycin exhibits bactericidal activity against a wide spectrum of aerobic gram-positive and gram-negative bacteria commonly responsible for uncomplicated UTIs. Fosfomycin Trometamol, a phosphonic acid derivative, works by irreversibly inhibiting the enzyme enolpyruvyl transferase, a key catalyst in bacterial cell wall synthesis. This inhibition disrupts peptidoglycan formation, leading to bacterial death.
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✔️ Side Effects of Fosamin
Common side effects (reported in over 1% of users) include:
- Gastrointestinal: Diarrhea (10.4%), nausea (5.2%), abdominal pain (2.2%), dyspepsia (1.8%)
- Neurological: Headache (10.3%), dizziness (2.3%), somnolence
- Other: Vaginitis (7.6%), back pain (3.0%), rash (1.4%), asthenia (1.7%), pharyngitis (2.5%), rhinitis (4.5%)
- Less common (<1%) adverse effects include: constipation, dry mouth, flatulence, insomnia, myalgia, migraine, nervousness, SGPT elevation, skin issues, and flu-like symptoms.
✔️ Dosage & Administration of Fosamin
For women aged 18 years and above, the standard dose is a single sachet of Fosamin, which can be taken with or without food.
This medication is not recommended for use in children.
Preparation Instructions:
- Pour 100 ml of purified water into a glass.
- Add the full contents of one sachet of Fosamin.
- Stir until fully dissolved and drink the solution immediately.
✔️ Drug Interactions
Concurrent use of metoclopramide, a drug that enhances gastrointestinal motility, may reduce the absorption and urinary levels of Fosfomycin. Other agents that increase gut motility may produce similar interactions, potentially lowering Fosamin’s effectiveness.
✔️ Fosamin should not be used in:
- Individuals with known hypersensitivity to Fosfomycin
- Patients with severe renal impairment
- Patients undergoing hemodialysis
✔️ Overdose Effects
Overdose data are limited. However, excessive gastrointestinal motility (from drugs like metoclopramide) may reduce the efficacy of Fosamin by lowering serum and urinary concentrations. Supportive care based on symptoms is advised in case of overdose.
✔️ Pregnancy & Lactation
Classified as Pregnancy Category B, Fosfomycin should only be used during pregnancy if the potential benefit justifies any potential risk. During breastfeeding, a decision should be made whether to discontinue nursing or to avoid the medication, weighing the importance to the mother.
✔️ Precautions & Warnings
- Use of Fosamin may lead to Clostridium difficile-associated diarrhea (CDAD), a potentially severe gastrointestinal condition.
- Do not repeat dosing: Single-dose therapy is effective; additional doses do not improve outcomes and may increase side effects.
- Discontinue use and seek medical advice if unusual gastrointestinal symptoms occur after treatment.
✔️ Storage Conditions
- Store in a cool, dry place below 25°C.
- Protect from light.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
